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Furthermore, caspase signaling pathway would be activated to induce cell apoptosis and the development of kidney diseases (Sinha et al., 2013

All participants also received standardized lifestyle counseling at baseline and every 4 weeks throughout the 12-week study period (detailed lifestyle guidance can be found in Supplementary Material 1)

Semaglutide belongs to a class of medications knownas glucagon-like peptide-1 (GLP-1) receptor agonists