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Description

Wegovy is a synthetic GLP-1 receptor agonist (RA)

Shtaya, M

Structural biology, including cryo-EM of retatrutide bound to each of its three target receptors, with deposited structures available in the PDB for comparative work

However, variation in individual risk profiles, driven by poor adherence and inconsistent behavioral change, as well as other factors, underscores the need for nuance in program design and application

This is likely due to its triple-action mechanism, which simultaneously targets appetite, insulin sensitivity, and energy expenditure