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MOTS-c, by contrast, works from the inside of the mitochondria outward, activating the same primordial energy-sensing cascade that millions of years of evolution have refined into the body's most fundamental metabolic regulator

Folates in the diet are predominantly the N 5 -methyltetrahydrofolate (5-methyl-THF or simply methylTHF) form

This suggests that GHK likely exists predominantly as GHK-Cu under normal physiological conditions (Pickart, 2008)

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