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Dominguez LJ et al

For instance, it can mitigate NSAID-induced gastroenteropathy and has been shown to rescue NSAID-cytotoxicity by stabilizing intestinal permeability and enhancing cytoprotection, including increasing tight junction protein ZO-1 expression

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Similarly, patients with active malignancy warrant careful consideration given theoretical concerns about angiogenic effects potentially affecting tumor growth, though preclinical evidence suggests context-dependent effects that may inhibit rather than promote tumor angiogenesis

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