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FIN56 promotes GPX4 degradation while depleting coenzyme Q10, creating a dual node pressure on the lipid antioxidant network that can overcome single target resistance and broaden ferroptosis induction across resistant states (87, 88)
Rather than targeting appetite or hormones, MOTS-c primarily affects cellular metabolism
Sci Rep 15(1):5457
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By being implicated in the pathophysiology of atherosclerosis and incorporated into ASCVD risk assessment models, lipoproteins are important prognostic indicators of cardiovascular health
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