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The models have been used to predict pharmacokinetics in special populations, including those with hepatic or renal impairment, as well as in disease states such as type 2 diabetes and obesity

CrossRef Risk of colorectal cancer in kidney transplant recipients and patients with end-stage renal disease undergoing hemodialysis Yongchel Ahn, Hoon Yu, Yoonjong Bae, Mina Kim, Seung Bum Lee The Korean Journal of Internal Medicine.2025

For example, a population-based cohort study in obese individuals without diabetes reported a fourfold increase in intestinal obstruction risk associated with GLP-1 RA use

Figure 1 These technologies are limited by their sensitivity to the subtle BBB changes that occur in early AD pathology and their ability to distinguish among AD, other neurological disorders, and inflammatory processes common in healthy aging

Ethics declarations Ethics approval and consent to participate All procedures and samples including cell line and animal experiment were approved by research ethics committee (REC) for experimental studies (human and animal subjects) at the National Center for Research Radiation and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt, (serial number F/6A/22) and in accordance with the Declaration of Helsinki