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Insulin resistance in adipose tissue, which is often related to obesity, compromises the inhibitory effects of insulin on adipose tissue lipolysis, leading to increased free fatty acids (FFAs) in portal circulation 4,5,6
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Semaglutide GLP-1 belongs to a class of medications known as GLP-1 receptor agonists
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However, the combined gastrointestinal burden may be more challenging to tolerate, and the risk of dehydration leading to acute kidney injury is increased
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