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Atorvastatin could induce ROS assembling massively in mitochondria, which was partially reduced by ferroptosis inhibitors of DFO, Fer-1 and Lip-1 in HCM (Figures 6A,C) and C2C12 (Figures 6B,D)

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Phase II: Conjugation Reactive intermediates from Phase I are bound to endogenous molecules, becoming water-soluble and less toxic

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