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This axis inhibits the presence of M1 macrophages, which are essential for antitumor immunity due to their pro-inflammatory and immune-activating properties

Its selectivity is a major point of interest for researchers because it boosts GH without a significant knock-on effect on other hormones, like the stress hormone cortisol

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[7] In parallel, Merck developed MK-677 (ibutamoren), a non-peptide oral GH secretagogue acting through the same receptor, demonstrating that small molecules could also activate this pathway