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On the muscle front, significant caloric restriction which is very common on these medications is linked to lean muscle loss when protein intake doesn't keep pace

In susceptible individualsparticularly those who are older, underhydrated, or taking nephrotoxic medicationsthis may increase the risk of acute kidney injury (30)

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The anticonvulsant valproic acid (Depakene) interferes with L-carnitine biosynthesis in the liver and forms with L-carnitine a valproylcarnitine ester that is excreted in the urine

Eating smaller meals, staying hydrated, and making small lifestyle adjustments can help reduce discomfort