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The primary theoretical safety concern is sustained activation of the HGF/c-Met proto-oncogenic pathway, which could theoretically promote tumor initiation or growth
[108] also suggested the possible role of probiotic bacteria, having ability to either deliver GSH or promote host GSH synthesis, in treatment of radiation induced enteritis and colitis
Finally, electrophilic diazenium diolates were designed as prodrugs for spontaneous nitric oxide (NO) release at physiological pH, after a reaction with GSH catalyzed by GST
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This makes it unique among the compounds discussed here, because it delivers a broad spectrum of neurotrophic factors rather than a single targeted signal
