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Short answer: It appears tolerable in very limited early human data, but there is not enough evidence to call it safe for general use

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- Direct delivery of functional ingredients through the oral mucosa, which has about 4,000 times the permeability of the epidermis

Carnitine acyltransferases may also be inhibited by sulfonylurea drugs, such as tolbutamide and glyburide, that are used in the treatment of the hyperglycemia of type 2 diabetes