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Allow vials to reach room temperature before opening to reduce condensation uptake

LEADER [29] and SUSTAIN-6 [30] reported a prespecified renal composite of new onset or persistent macroalbuminuria, persistent doubling of serum creatinine and eGFR 45 mL/min/1.73 m 2 , need for renal replacement therapy (RRT), and renal death

Indeed, metabolomic profiling of cerebrospinal fluid samples from patients with HE has demonstrated impaired cerebral energy metabolism, supporting the presence of brain energy deficiency in this population [26]

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