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However, magnetic resonance imaging (MRI) is the most specific and sensitive test for detecting bone disease and soft tissue involvement in MM ( 2.2 Mechanism of MM pathogenesis The pathogenesis of MM is a complex process leading to the replication of a malignant plasma cell clone that originates from the lymphoid B-cell lineage and develops after lineage commitment in the bone marrow ( Multiple mechanisms for MM cell dysregulation have been described, such as translocations of the Cyclin D1 gene with the IgH gene, specific Cyclin D gene amplifications, trisomies, and other cytogenetic events ( Dysregulation of cyclin D appears to be a necessary occurrence in the establishment of abnormal plasma cells
In studies, l-carnitine has demonstrated the ability to promote oxygenation of heart muscle and maintain healthy enzyme activity, support cardiovascular energy, enhance exercise recovery, and maintain healthy lipid metabolism.* Uses For l-Carnitine Cardiovascular Support: A randomized double-blind placebo-controlled trial involving 101 volunteers indicated that l-carnitine maintained healthy lipid peroxide and lactate dehydrogenase cardiac enzyme activity
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