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The main concern is that persistent nausea, vomiting, or diarrhea may cause dehydration and reduced kidney perfusion

This variant alters the 354th amino acid of the protein sequence from glutamic acid (G allele) to glutamine (C allele

In addition, this sparing effect can also indicate an inhibition of the one-carbon unit-providing action of glycine to the N 510 -methylene-tetrahydrofolate-dependent remethylation of Hcy (Fig