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Starting with smaller amounts allows the human body to adjust gradually

These conditions can change how often and how much B12 you need

Further studies are needed to confirm the lower B12 levels in relation to obesity or semaglutide use, and their effect when combined with GLP-1 drugs

Certain medications The following drugs can reduce levels of vitamin B12 in your body: Antibiotics -- long-term use can lower vitamin B levels generally Anti-seizure drugs Chemotherapy medicines, especially methotrexate Drugs used to reduce stomach acid, like H2 blockers (Pepcid AC, Tagamet, Zantac) and proton pump inhibitors (Nexium, Prevacid, Prilosec) Metformin (Glucophage) -- taken for diabetes Colchicine -- taken for gout Some cholesterol-lowering medications Other causes You're over 65

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