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This is exactly why the REDEFINE 4 trial exists

First-line medications for neuropathic pain and allodynia include the following options

The 21 day rule is a hard limit

Thats just a drug company strategy for getting a broader indication for these medications rebranding them and marketing them for weight loss. The cost of a GLP-1 medication may be intimidating in that one needs to remain on the drug long-term to maintain its effect for diabetes, weight loss, or perhaps a reduction in depression and anxiety

growthhormone secretagogues (Sermorelin, Ipamorelin) boost endogenous HGH, supporting restorative sleep cycles