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According to a 2017 study, mushrooms are among the most significant dietary sources of glutathione and ergothioneine, the latter of which is a sulfur amino acid

tree, digoxin (cardiac glycoside) from Digitalis purpurea , ephedrine from Ephedra sinica , lovastatin from Monascus purpureus L., taxol from Taxus brevifolia , reserpine from Rauvolfia serpentina , and many others (Harvey, 2000

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the most significant safety concerns are associated with high-dose, unregulated use in non-clinical settings