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Recent multisociety practice guidelines have offered more clarity for clinicians who provide sedation outside the operating roomincluding dentists, endoscopists, and proceduralistswhen treating patients on GLP-1 receptor agonists (GLP-1 RAs) like Semaglutide, Ozempic, or Wegovy.sciencedirect Key Recommendations: Shared Decision-Making: Management should involve the patient and all relevant care teams (procedural, anesthesia, prescribing), considering metabolic needs and individual risk factors