In December 2023, the FDA issued a warning about compounded semaglutide products, noting that some contained salt forms of semaglutide (such as semaglutide sodium or semaglutide acetate) that differ from the base form in the FDA-approved products
GLP-1 receptor agonist products mimic that hormone, and are used for Type 2 diabetes management and weight loss
Plans cover the diabetes-labeled drugs (Ozempic, Mounjaro) far more often than the weight-loss ones (Wegovy, Zepbound)
Hydration supports normal blood volume, reduces stress signaling, and allows the lymphatic system to move fluid more effectively
Such concerns necessitate a more nuanced approach to perioperative care, where anesthesiologists must not only evaluate the patients diabetic or weight management status but also carefully assess the impact of GLP-1 RA use on gastric emptying and anesthesia risk (Joshi et al