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GLP-1 agonists interrupt this cycle by directly binding receptors in the hypothalamusthe brain's appetite command centerand by reducing systemic inflammation that interferes with leptin signaling

doi: 10.1002/ehf2.12633 307 NewtonDJKennedyGChanKKLangCCBelchJJKhanF

GHRH belongs to the secretin family of evolutionarily related hormones, part of a larger superfamily including the glucagon family of peptides [12]

While its efficacy profile is compelling, it remains an investigational compound requiring further long-term safety and regulatory evaluation before widespread clinical adoption

GLP-1 Receptor Agonist Discontinuation Among Patients With Obesity and/or Type 2 Diabetes