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Hence, it can be concluded that there is a 13-fold increase in the bioavailability of diosgenin due to presence of piperine

Boxplots showing the concentrations (y-axis) of the significantly altered metabolites in control (n = 9), compared to 50 (n = 9), 35x6 (n = 9), and 4+1 (n = 9) treatment groups analyzed by one-way ANOVA, p-value 0.1)

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Mechanism: Four Pathways, One Stack Each pathway maps to different receptors and partially distinct brain regions

Epithalon also appears to inhibit the activity of Caspase-3, a key enzyme that is considered to promote apoptosis (programmed cell death)