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15 Combating therapeutic resistance thus requires an integrative, precision-driven approach that includes novel drug combinations, adaptive treatment regimens, microenvironmental reprogramming and rational modulation of hostmicrobetumor crosstalk

doi:10.1038/nature08467 Kasahara A, Scorrano L (2014) Mitochondria: from cell death executioners to regulators of cell differentiation

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This can lead to fatty liver disease in both those who misuse alcohol and those who dont