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Resistance to MAPK inhibitors in melanoma involves activation of the IGF1R-MEK5-Erk5 pathway

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Last Updated: April 1, 2026 | Reading Time: Approximately ~9 minutes | Author: Palmetto Peptides Research Team Quick Answer Hexarelin and ipamorelin are both synthetic GHS-R1a agonists studied for their ability to stimulate growth hormone release in preclinical research models

It also increases fibroblast proliferation and collagen synthesis through the FAK-paxillin and GHR pathways