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The sustained receptor activation achieved by semaglutide produces more pronounced and consistent metabolic effects compared to the pulsatile, meal-related actions of endogenous GLP-1
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The marginal probabilities follow as column- or row-wise additions in p rs , for example, the probability that r k = 0 is p r =0 = p 00 + p 01
Effects on classic cardiovascular risk factors CVOTs on GLP-1RAs Data from the major CVOTs ELIXA, SUSTAIN-6, EXSCEL, HARMONY, PIONEER 6, LEADER, REWIND, and AMPLITUDE-O [53, 54, 56, 59,60,61,62,63] support the overall safety of GLP-1RAs relative to major cardiovascular outcomes
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