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JAMA 322(13):12941304 Kovesdy CP (2022) Epidemiology of chronic kidney disease: an update 2022
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All data is sourced from published literature (references at the end)
The histidine residue serves as the primary copper-binding site, while the lysine residue contributes to cellular uptake through electrostatic interactions with negatively charged cell membranes
This new understanding could shift the focus of therapeutic interventions towards managing the condition by directly targeting these hormonal pathways alongside regulating cysteine metabolism
But it is newly relevant
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