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Ligand binding drives receptor autophosphorylation, IRS-1/IRS-2 adapter recruitment, and activation of two primary downstream cascades: PI3K/Akt/mTOR (governing protein synthesis, glucose uptake, and cell survival) and MAPK/ERK (regulating cell proliferation and differentiation)
glaucoma Pharmacokinetics: admimnistered as eye drops acts in 15-30 minutes, with a duration of 3-8 hours
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there are other additional options to add to help boost weight loss, especially in the setting of becoming stagnant while on max dose or upon transitioning off of a GLP-1RA
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