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In the UK, adults with confirmed B12 deficiency and neurological symptoms typically receive hydroxocobalamin injections1 mg intramuscularly on alternate days until symptoms stabilise, followed by maintenance doses every two months

Less Common Effects Systemic effects occur less frequently and typically involve mild, transient symptoms

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Importantly, peripheral arthritis remains radiologically stable in AxSpA patients under infliximab, especially in the hip [39], resulting also in reduced hip replacement surgery rate [40, 41]

Tirzepatide: Another Relevant Comparison Tirzepatide (Mounjaro/Zepbound), a dual GIP/GLP-1 agonist approved by the FDA, provides another useful reference point