For the researchers, parenteral high-dose thiamine was effective in reversing Parkinsons disease symptoms, that a dysfunction of thiamine-dependent metabolic processes could cause selective neural damage in the centers typically affected by this disease and that Thiamine could have both restorative and [nerve-protecting] action in Parkinsons disease. Source: Costantini, Antonio, Maria Immacolata Pala, Enzo Grossi, Stella Mondonico, Luisa Ercoli Cardelli, Carina Jenner, Sabrina Proietti, Marco Colangeli, and Roberto Fancellu
doi: 10.1007/s10815-005-5149-2 82 GarridoNNavarroJRemohJSimnCPellicerA
Take 2-4 capsules daily with food, or as directed by a qualified health care practitioner
PloS ONE 9 , e112965 (2014)
The cost comparison reveals the fundamental issue: patches offer the lowest cost but also zero evidence of efficacy