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Tesamorelin directly stimulates the growth hormone-releasing hormone (GHRH) receptor, amplifying endogenous GHRH signaling
This study demonstrated the importance of combined GLP-1R and GCGR signalling, as administration of the balanced co-agonist to Glp1r -/- mice led to hyperglycaemia, further demonstrating the necessity of GLP-1R and GCGR co-agonism to minimise this predicted side-effect
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