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Unlike native IGF-1, the LR3 variant does not bind strongly to IGF Binding Proteins (IGFBPs)

Length of treatment and patient adherence to taking medication are also important

Another randomized controlled trial showed that soybean isoflavone therapy (80 mg/day, P.O for 24 weeks) significantly increased the protein and mRNA levels of Nrf2 and the concentrations of SOD as well as diminished serum levels of inflammatory factors and MAD in patients with myocardial ischemia [139]

O'Rourke EA, Balzer B, Barry CI, Frishberg DP