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Semaglutide, on the other hand, predominantly focuses on GLP-1 receptor activation

Several ionic mechanisms such as non-selective cation channel, voltage-dependent potassium channel, and TRPC5 channel may be associated with activation of GLP-1R-induced electrophysiological effects (Figure 1A)

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There have been post-marketing case reports of severe delayed gastric emptying, though this is not listed as an established adverse reaction in the UK Ozempic SmPC

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