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It is typically dosed subcutaneously at 50-100 mg daily to ensure high bioavailability and avoid adverse gut metabolism
Reconstitution volume is a measurement-resolution decision, not a fixed rule
A significant aspect of this study was the administration of a high dose (50 mg/kg) to evaluate the absorption profile effectively, overcoming the challenge posed by the endogenous production of GSH which could mask the effects of supplementation
In trials (DURATION program), once-weekly exenatide 2 mg showed slightly more A1c reduction (~1.5% drop from baseline 8.3%) than Byetta BID (~1.0% drop) with fewer GI side effects after initial weeks ( [6] )
Presented for research literature review only Halder M et al
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