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AOMs, including liraglutide and semaglutide, combined with lifestyle intervention could offer an upgraded treatment strategy for patients with PCOS and obesity (28)

While all GLP-1 agonists share some common gastrointestinal effects, the triple agonism of retatrutide introduces glucagon receptor-mediated effects that the others do not produce

GIP influences fat tissue directly, affecting how the body stores and mobilizes energy

Specifically, it suggests that GLP-1 drugs could act upon impulse control and stress-reward systems in the brain relating to substance and alcohol misuse