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The increased level of inflammatory cytokines is perhaps a result of dysbiosis of the gut microbiota, which may further weaken the integrity of the gut barrier
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Once in circulation, GLP-1 is rapidly degraded by DPP-4, which cleaves the active hormone to form GLP-1(9-36) with significantly reduced insulinotropic activity
( a - h ) Metabolic phenotype of standard chow-fed lean mice
Microbial metabolites, including bile acid derivatives and short-chain fatty acids (SCFAs), can influence endogenous GLP-1 secretion and activity
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