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Side effects of prednisone Common side effects, especially at high doses (40 mg/day or more) or long-term use, include: Insomnia Mood changes Muscle weakness Fluid retention Increased appetite and weight gain Nausea and stomach pain Bloating Headache and dizziness High blood sugar and high blood pressure Serious side effects requiring immediate attention include: Increased risk of infections (avoid exposure to measles or chickenpox) Eye problems (glaucoma, cataracts