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that is, cleavage activity on single-residue substitutions is predictive of cleavage activity on combinations of those substitutions (Supplementary Fig
This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from nave GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38
The researchers felt that N-acetylcysteine and glutathione could accomplish this by protecting the DNA from free radical damage
Presented for research literature review only Kleiverda G (1996)
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