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The specific molecular linkages among these systems and pathogenesis, on the other hand, are unknown and controversial

This contributed to a higher discontinuation rate for tirzepatide (13.2% vs 10.1%)

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So in general, there is a very nice effect, good effect on the vascular system, and of course, the vascular system is common for the entire body, so the kidneys and the liver and the heart and what have you, everything, also the brain

Reasonable confounding factors did not significantly affect the validity of the results, leading to a high quality of evidence rating for these outcomes (Table 4)