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Antioxidant enzyme upregulation protects photoreceptors and RPE from oxidative damage

This distinction is maintained throughout the manuscript to avoid conceptual dilution and to clearly differentiate between true circadian entrainment and indirect modulation of circadian function ( Age-related declines in melatonin secretion and signaling have been consistently associated with circadian rhythm dampening, sleep fragmentation, increased oxidative stress, and chronic low-grade inflammation, all hallmarks of biological aging