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The Phase 2 trial enrolled participants with obesity and evaluated multiple dose levels over 48 weeks: 1 mg dose: 8.7% average body weight reduction 4 mg dose (escalated from 2 mg): 17.1% average body weight reduction 8 mg dose (escalated from 2 mg): 22.8% average body weight reduction 12 mg dose (escalated from 2 mg): 24.2% average body weight reduction Placebo: 2.1% average body weight reduction Those Phase 2 numbers were striking enough

[1] For gut health applications, the oral route has the most direct mechanistic support

Adjusting Dose by Body Weight The standard dosage chart assumes an average adult of 60 to 85 kg

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Site rotation prevents localized reactions, with common areas including the abdomen (2+ inches from navel), outer thighs, and upper arms