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Preclinical studies indicate potential roles in: Supporting healthy fat metabolism and reduction of adipogenesis Improving insulin sensitivity in metabolic research models Enhancing NAD+ salvage pathway efficiency Exploring effects on energy homeostasis and longevity pathways These findings remain preliminary and confined to laboratory and animal models

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NNMT inhibition as a therapeutic strategy has been explored in industry pharmaceutical pipelines (including a Pfizer program for non-alcoholic fatty liver disease that was reportedly discontinued in early clinical development), but no NNMT inhibitor has reached regulatory approval to date

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