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Although semaglutide and SGLT2i have complementary and nonoverlapping mechanisms of action, the present study cannot determine whether background therapy with SGLT2i might have influenced the treatment benefits observed, which is an important question for future trials

However, given its weight loss effects, Mounjaro was also being used "off label" to treat obesity

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Instead of triggering a hormonal response, it acts directly on metabolic enzymes at the cellular level

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