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Sustained glial activation drives neuroinflammation in a vicious cycle via reactive oxygen species (ROS), cytokines, and chemokines (Thakur et al., 2023)

Extracellular NAMPT (eNAMPT) is secreted from adipocytes and immune cells 43,44 via exosomes, and enters the circulation, allowing transport of this enzyme to other tissues

Inflammation Regulation Chronic inflammation is a common underlying factor in many chronic diseases

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HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction