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The primary available study, Naessen et al

Kojic acid helps inhibit melanin production, while liquorice extract provides gentle lightening effects

Across these CEAs, relative to insulin, the use of a GLP-1RA could be dominated or had an ICER of US$22,682 to US$90,646 per QALY gained from the payer perspective, an ICER of US$1982 to US$42,679 per QALY gained from the healthcare sector perspective, and an ICER of US$21,488 to US$28,490 per QALY gained from the societal perspective

The developments come as the two companies are in intense competition in the GLP-1 space

The number of biological replicates per condition was 4 for all conditions apart from GLP-1-stimulated samples, which included 3 replicates