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Fourth, long-term clinical outcomes data - cirrhosis incidence, HCC rates, liver transplantation, and liver-related mortality assessed as primary endpoints in randomized trials - are not yet available and are urgently needed to move beyond surrogate histological endpoints
Joint pain, stiffness, swelling, and reduced mobility often affect sleep, exercise, work, and overall quality of life
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Ethical considerations in medical use There are many ethical issues to be concerned about in the medical use of hyaluronidase, and the safety risk and informed consent need to be considered first, the possible allergic reactions caused by animal-derived hyaluronidase, whether long-term application of hyaluronidase can degrade hyaluronan in normal tissues, such as skin laxity, decreased joint stability, etc
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