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Metabolites 12 , 173 (2022)

After 8 weeks of treatment, tirzepatide significantly reduced fasting plasma glucose levels, HbA1c levels (a measure of long-term blood sugar control), and body weight compared to the placebo

There are other forms of bias in these datasets including channeling (e.g., the prescribing pattern depends on a patient characteristic (particularly diabetes or obesity) that is a PDAC risk factor), detection (e.g., overreporting due to additional testing to rule out a suspected adverse event (e.g., imaging triggered by pancreas enzyme elevations)), and Weber effect (initial increase in event reporting shortly after drug launch) 49

Iron metabolism: pathophysiology and pharmacology