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This explains why researchers observe sustained benefits during the off-cycle period
But the overall takeaway is that it is challenging to stay on these medications, even in clinical trial conditions
Mild Side Effects Patients may occasionally experience: Nausea Mild headache Injection site discomfort These effects are usually temporary and resolve quickly
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Hence, in 2022, glucose-lowering efficacy and proven cardiovascular effects were important for the strong positioning of semaglutide, dulaglutide and tirzepatide in guidelines on the management of hyperglycaemia in type 2 diabetes [33], and a similar strong positioning of incretin therapy was seen in guidelines on primary care [39]
