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Rather than being driven by cardiomyocyte loss and impaired systolic function, HFpEF develops in the context of systemic comorbiditiessuch as hypertension, T2DM, coronary artery disease (CAD), chronic kidney disease (CKD), anemia, AF, obesity, and pulmonary diseasethat contribute to a chronic low-grade inflammatory state
Food Hydrocoll 95:7687
Early research has not found an increased risk of major developmental issues during early pregnancy from GLP-1 exposure
2 trials
Some people who took retatrutide in the trials (about 7%) reported unusual skin sensitivity or more sensitive skin, but these symptoms werent severe enough to discontinue treatment
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