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Sustained immune activation may affect: Neurological function and cognitive processing Autonomic nervous system regulation Hormonal signaling and endocrine stability Mitochondrial energy production Gut barrier integrity Vascular and endothelial function Rather than remaining localized to the respiratory system, inflammation becomes systemic

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10.1007/s12035-014-8705-x 76 MoyseE.KranticS.DjellouliN.RogerS.AngoulvantD.DebacqC.et al (2022)