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In the first half reaction, NADPH reduces FAD present in glutathione reductase to produce a transient FADH- anion, which breaks a disulfide bond of Cys58 - Cys63, forming a short-lived covalent bond between the flavin and Cys63
& Caudill, M
The mitochondria may be the powerhouse of the cell, but mounting evidence suggests this organelle is also a driving force behind cancer
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